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Abbott Statement on Advancing Pediatric HIV Treatment in ...

... Patients should discuss all medicines, including those without a prescription and herbal products that they are taking or plan to take, with their doctor or pharmacist.Pancreatitis and liver problems, which can be fatal, have been reported in patients receiving lopinavir/ritonavir.

Patients should tell their doctor if they have nausea, vomiting, or abdominal pain, which may be signs of pancreatitis, or if they have or have had liver disease such as hepatitis B or C.

In patients taking protease inhibitors, increased bleeding (in patients with hemophilia) and diabetes/high blood sugar have occurred.Changes in body fat have been seen in some patients receiving anti- retroviral therapy.

The cause and long-term health effects of these conditions are not known at this time.

Some patients receiving lopinavir/ritonavir have had large increases in triglycerides and cholesterol.

Varying degrees of cross-resistance among protease inhibitors have been observed.The most commonly reported side effects of moderate severity are: abdominal pain, abnormal bowel movements, diarrhea, feeling weak or tired, headache, and nausea.

Children taking lopinavir/ritonavir may sometimes get a skin rash.

This is not a complete list of reported side effects.Diarrhea may be more common in patients taking lopinavir/ritonavir capsules once-daily compared to the twice-daily dose (57 percent...

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